Blood clots

Del Boy Scientists Discover Clotshot ‘Trigger’

Our American friends might not appreciate the subtle headline above, most likely because they are unaware of the highly successful and much loved UK comedy series ‘Only Fools and Horses’. Del Boy and Trigger are both characters in that sitcom.

I use the headline mockingly, to illustrate the absurdity of UK mainstream ‘news’. This isn’t news. it’s not ‘newly discovered’. It’s not really ground-breaking scientific research. In fact, it’s been known about for years, even before the advent of the Covid-19 ‘vaccines’. I wrote about it here.

The BBC and the rest of the MSM here in the UK are making a big deal about it. This is the BBC headline:

Covid: Trigger of rare blood clots with AstraZeneca jab found by scientists

Shouts at you. Makes you think that some new and exciting scientific discovery has happened. It hasn’t. They may have uncovered more details about the mechanism involved. That’s it basically. All that’s happened is that Del Boy has discovered that Trigger has replaced the handle on his old broom.

The BBC say:

Scientists believe they have found “the trigger” that leads to extremely rare blood clots after the Oxford-AstraZeneca Covid vaccine.

The team – in Cardiff and the US – have shown in exquisite detail how a protein in the blood is attracted to a key component of the vaccine.

They think this kicks off a chain reaction, involving the immune system, that can culminate in dangerous clots.

It also started a scientific detective hunt to figure out what was going on and if it could be prevented. The Cardiff team were given emergency government funding to find the answers.

Ooh, really? A real life detective hunt!

The researchers thought the adenovirus might be linked to the rare clots occurring in some people.

They did? Why’s that I wonder? Could it have something to do with the fact that adenovirus vectors were implicated in blood clotting years ago? Surely not! I wrote about this very topic in the reference above:

The issue has been known about for at least 15 years, so there’s no excuse for the manufacturers to claim that such an adverse effect was unforeseen – it wasn’t. Here for instance:

Thrombocytopenia has been consistently reported following the administration of adenoviral gene transfer vectors. The mechanism underlying this phenomenon is currently unknown.

And here:

Thrombocytopenia is a major adverse effect of high dose systemic administration of adenoviral (Ad) gene therapy vectors. While a previous report did not find platelet activation by Ad [1], recent studies have shown that Ad may activate platelets [2] and binds in vivo to murine thrombocytes resulting in hepatic sequestration [3]. Ad-induced thrombocytopenia has been shown to be dose-dependent, saturable and reversible [4], compatible with a ligand-receptor mechanism. Recently, binding of Ad to platelet was indirectly suggested following interference of platelet adhesion to fibronectin after incubation with Ad [2]. In this study we developed a direct flow cytometry assay to quantitatively analyze Ad attachment to human platelets in vitro and to characterize their interaction.

So any claims of ‘new discovery’ by the press are total bullshit and moreover they conceal the fact that the manufacturers of the Oxford/AZ chimp virus ‘vaccine’ must have known from the word go that their product carried a significant risk of inducing blood clots.

They even knew a lot about the mechanism of the binding of the adenovirus to platelets way back in 2009 and this scientific study describes it in detail, which sounds suspiciously similar to the mechanism ‘newly discovered’ by Del Boy scientists today – though I’m not an expert judge in that respect. The point is, scientists knew that adenoviral vectors were a potential problem 10 years before the Covid ‘vaccines’ appeared on the scene. Just how gullible and stupid do the main stream press think we are?

SARS-CoV-2 Spike Protein Causes Novel Inflammatory Blood Clotting

This paper has just been published. It’s a preprint so hasn’t been formally peer-reviewed, and that should be borne in mind when analysing its conclusions.

Here we report that the Spike protein from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the blood coagulation factor fibrinogen and induces structurally abnormal blood clots with heightened proinflammatory activity. SARS-CoV-2 Spike virions enhanced fibrin-mediated microglia activation and induced fibrinogen-dependent lung pathology. COVID-19 patients had fibrin autoantibodies that persisted long after acute infection. Monoclonal antibody 5B8, targeting the cryptic inflammatory fibrin epitope, inhibited thromboinflammation. Our results reveal a procoagulant role for the SARS-CoV-2 Spike and propose fibrin-targeting interventions as a treatment for thromboinflammation in COVID-19.

Persistent life-threatening thrombotic events are a hallmark of COVID-19. Aberrant clots form in multiple organs causing significant morbidity and mortality in COVID-19 patients (1, 2). The high incidence of clotting complications has been attributed to disease severity, inflammation and subsequent hypercoagulable state (3). However, the clinical picture is puzzling because of disproportionate rates of thrombotic events and abnormal clot properties not observed in other inflammatory conditions, such as severe sepsis or different viral respiratory illnesses (4-7).

The central structural component of blood clots, and a key regulator of inflammation in disease, is insoluble fibrin, which is derived from the blood coagulation factor fibrinogen and is deposited in tissues at sites of vascular damage (10, 11). Hypercoagulability in COVID-19 is associated with inflammation and the formation of fibrin clots resistant to degradation despite adequate anticoagulation (3-5).

The high prevalence of thrombotic events with these unique hypercoagulability features suggests an as yet unknown mechanism of abnormal blood clot formation in COVID-19. We set out to determine how blood clots form in COVID-19 and to identify therapies to combat the deleterious effects of abnormal coagulation occurring in acute and convalescent stages of disease. Since hypercoagulability in COVID-19 patients has features distinct from those of other inflammatory diseases, we hypothesized that SARS-CoV-2 directly affects the structural and functional properties of blood clots.

So what we have is a virus which, in a relatively few serious cases, mainly in older people and those with co-morbidities, causes a unique form of pro-inflammatory blood clotting which has not been observed in other respiratory diseases and in fact appears to be a phenomenon new to medicine. It is these structurally abnormal clots which are responsible for many of the fatalities associated with SARS-CoV-2 infection.

What is causing these ‘structurally abnormal’ blood clots? The authors identify the SARS-CoV-2 spike protein as the culprit, the mechanism which involves the binding of the spike to one of the key ingredients of blood clots, fibrin:

The central structural component of blood clots, and a key regulator of inflammation in disease, is insoluble fibrin, which is derived from the blood coagulation factor fibrinogen and is deposited in tissues at sites of vascular damage (10, 11). Hypercoagulability in COVID-19 is associated with inflammation and the formation of fibrin clots resistant to degradation despite adequate anticoagulation (3-5).

Overall, these results reveal an unanticipated role for SARS-CoV-2 Spike as a fibrinogen binding protein that alone accelerates the formation of abnormal clots with altered structure and increased inflammatory activity.

It’s not the virus causing this damage; it’s the spike protein alone. The biologically engineered spike protein, in all likelihood. Fauci’s biologically engineered spike protein, that is.

The high prevalence of thrombotic events with these unique hypercoagulability features suggests an as yet unknown mechanism of abnormal blood clot formation in COVID-19.

I bet it’s not unknown to Fauci and his co-conspirators who designed this virus and, with the help of the CCP, unleashed it upon an unsuspecting world. You think maybe that’s a tin foil hat too far? I don’t think so. A huge amount of evidence now points to the man-made origin of the SARS-CoV-2 virus and its deliberate or, less likely, unintentional release to create a planned pandemic. You might want to pre-order Robert F. Kennedy Jr.’s book on Fauci and his role in creating this plandemic and corrupting medical science along the way.

Since hypercoagulability in COVID-19 patients has features distinct from those of other inflammatory diseases, we hypothesized that SARS-CoV-2 directly affects the structural and functional properties of blood clots. Incubation of SARS-CoV-2 recombinant trimeric spike protein (Spike) with healthy donor plasma increased fibrin polymerization (Fig. 1A). Spike strikingly altered the fibrin clot structure resulting in thinner fibers with a rough appearance and increased clot density as shown by scanning electron microscopy (SEM) (Fig. 1B, fig. S1),

It’s not just spike proteins building abnormal blood clots which is a problem though, it’s even worse. The spike-induced fibrin accumulation at bodily sites actually causes more inflammation:

Fibrin is deposited locally at sites of vascular damage and is a potent proinflammatory activator and a key inducer of oxidative stress (11, 18). Strikingly, Spike increased fibrin-induced release of reactive oxygen species (ROS) in a concentration-dependent manner in bone marrow derived macrophages (BMDMs), while Spike alone did not have an effect (Fig. 1G). These results suggest a role for Spike as an enhancer of fibrin-induced inflammation at sites of vascular damage. Overall, these results reveal an unanticipated role for SARS-CoV-2 Spike as a fibrinogen binding protein that alone accelerates the formation of abnormal clots with altered structure and increased inflammatory activity.

If the SARS-CoV-2 full length spike protein architecture is indeed a product of man, not nature, then it is quite obviously designed to be a lethal bioweapon of particularly fiendish effectiveness.

These results reveal a Spike–fibrinogen-dependent mechanism of clot formation that generates strong inflammatory and oxidative stress responses.

Fibrinogen is causally linked to the activation of macrophages and microglia in autoimmune and inflammatory diseases in the brain and periphery (11, 21). Fibrin is a driver of microglia-induced cognitive dysfunction (22) and is associated with perivascular-activated microglia and macrophages in brains of COVID-19 patients even without signs of infection (12).

Nasty. The authors summarise their findings as follows:

In summary, we find that SARS-CoV-2 Spike protein enhances the formation of highly inflammatory clots that are neutralized by a fibrin-targeting monoclonal antibody. Our data shed new light on the enigmatic coagulopathy found in COVID-19 revealing a causal role for fibrinogen in thromboinflammation – even independent of active viral replication. The high incidence of clotting complications in COVID-19 has been attributed to systemic inflammation (3), vascular damage including abnormal levels of circulating coagulation proteins (1, 26), genetic susceptibility to tissue factor and complement genes (27), and prothrombotic autoantibodies (28). Our findings now show that coagulopathy is not merely a consequence of inflammation. Rather, the interaction of SARS-CoV-2 Spike with fibrinogen and fibrin results in abnormal blood clot formation that in turn drives inflammation. Identification of SARS CoV-2 Spike protein as a fibrinogen binding partner provides a mechanistic basis for the formation of abnormal clots with enhanced inflammatory properties.

A vicious circle. Coagulation is not merely a result of inflammation, it causes inflammation also, a process driven by the presence of the spike protein alone and its peculiar interaction with fibrinogen and fibrin.

Now here’s the kicker. If the SARS-CoV-2 virus with its uniquely pathogenic spike protein is a bioweapon, then so also must be the ‘vaccines’, which cause the cells in our bodies to manufacture SARS-CoV-2 spike proteins in their trillions, and it has been demonstrated conclusively that these spikes find their way into the vascular system and circulate to every organ in the body, even the brain. Go figure, as they say.

Oxford/AstraZeneca Vaccine & Blood Clots – the Shifting Sands of Evidence

It’s strange isn’t it, that days after Mike Yeadon and other scientists wrote to the European Medicines Agency warning of the potential for serious thrombolic adverse reactions associated with the Covid ‘vaccines’, many countries in Europe put a temporary hold on vaccinations with AZ whilst the EMA and the German regulator looked into it. The British government claimed there was no evidence of any link between the AZ jab and blood clots and Pol Pot Belly went live on TV to get the AZ jab despite earlier claiming that he was ‘bursting with [natural] antibodies’.

The EMA then reversed their decision, despite there being evidence that there was a significant increased risk of this very rare form of blood clotting in women under 60 administered with the vackseen. The vaccine was ‘safe and effective’ they said and there was no evidence of a link with rare blood clotting and the benefits outweighed the risks, blah, blah, blah, despite the fact that the risk to healthy women under 60 from Covid-19 is tiny.

But now, Germany has suspended the use of AZ in the under 60s and the EMA has changed its tune. In the Mail:

One of the European drug regulator’s senior officials today claimed there is now a ‘clear’ link between AstraZeneca’s Covid vaccine and potentially deadly blood clots.

Marco Cavaleri, head of vaccines at the European Medicines Agency (EMA), said that CVST — a brain blockage that can lead to a stroke — was occurring more often than expected in younger people.

But he admitted that the body was still baffled about how the jab may trigger the rare complication.

Despite his comments, Mr Cavaleri’s agency has repeatedly insisted AstraZeneca’s jab is safe and the benefits outweigh any risks. 

Last week it slapped down Germany for suspending its use in under-60s, arguing there was ‘no evidence’ to support age-based restrictions.

But at the same time, the watchdog paved the way for a potential U-turn, warning that the rate of the complication did appear to be slightly higher than expected in vaccinated under-60s. 

Experts across the board say the evidence is now ‘shifting’ and that the jab is likely – in extremely rare cases – to cause the brain blockage.

‘Shifting’ . . . . yeah, right. It was there in the first place. First they took notice, then they dismissed it, no doubt for political reasons, then they were forced to look at it again because incidences of blood clotting in vaccinees kept happening.

The MHRA have not yet moved to restrict AZ vaccinations and Pol Pot Belly was out in Macclesfield a few days ago promoting the jab, no doubt thinking at the time that he would be announcing the introduction of vaccine passports, having not anticipated the strength of opposition to them.

Boris Johnson today called on Britons to still get the jab while on a visit to an AstraZeneca factory in Macclesfield, saying the ‘best thing’ they can do is ‘look at what the MHRA say’. He added: ‘Their advice to people is to keep going out there, get your jab, get your second jab.’

But he glossed over questions about whether the UK could impose a ban on the jab for under-30s.

Of course, the hard-nosed statisticians claim that the chance of a person dying from Covid in the younger age groups is still much higher than the chance of dying from the rare form of CVST blood clotting. The Mail reproduces this graph:

Convincing isn’t it? Except for the fact that it completely ignores:

/ Covid deaths in the 25-44 age groups are overwhelmingly those with serious underlying illness, both male and female.

/ AFAIA CVST events are mainly in younger women with no underlying health issues who are at much less risk of dying from Covid-19 than is the impression given by that chart.

/ ‘Covid deaths’ are almost certainly overestimated, therefore the risk of dying from Covid is also overestimated.

/ Other adverse reaction risks are associated with being jabbed (there are many), including unknown long term risks.

So why would any sane, healthy woman (or man even) under 60, but particularly under 45, opt to get jabbed with an experimental ‘vaccine’ with demonstrable serious side effects (including CVST) and unknown future long term health effects supposedly in order to ‘protect’ themselves against a disease which, if they were to contract, would probably present as no worse than a bad cold, if they were unlucky? Most liklely answer: because the government told them they wouldn’t be able to go on holiday if they didn’t! But it’s the vaccine refuseniks who are ‘selfish’ apparently.